Microscopic histologic description. A prototype of septal panniculitis, characterized by vascular changes, septal inflammation, hemorrhage and variable acute and chronic panniculitis Both septal and lobular panniculitis Marked septal fibrosis, infiltrated by lymphocytes, neutrophils, histiocytes and granulomas with giant cells Septal infiltrate spills over to affect the fat lobules Dermis shows perivascular and periadnexal chronic inflammatory cell infiltrate Early, the septal inflammation is acute and characterized by neutrophils, soon replaced by lymphocytes and histiocytes Variable eosinophils, variable vasculitis Miescher radial granuloma: characteristic finding of erythema nodosum; septal collection of histiocytes surrounding a cleft appear to look like spaces ; reported in Sweet syndrome, nodular vasculitis and necrobiotic lipodica.
Differential diagnosis. Nodular vasculitis or subacute nodular migratory panniculitis: usually septal Weber-Christian disease associated panniculitis: usually lobular inflammation. Author content All content in this area was uploaded by Neelam Sood on Oct 25, Upgrading type1 lepra r eaction or r eversal reaction RR is an acute inflamma tory complication of leprosy and. Inter-observe r variations among.
The pathologists were blinded to the clinical diagnosis. Each pathologist assigned a likelihood of reaction by their hist opathological. Clinicopathological correlation and. Discordance between clinical and hist opathological.
Dermal edema, intragranuloma edema and epidermal erosion wer e consistent findings by all observers. Kappa statistics for strength. Received : Correspondence to: Avninder Singh Email: avninders hotmail. Histopathological Diagnosis of Leprosy T ype 1 Reaction. Leprosy remains a health problem in diff erent. At the end of first quarter of. Leprosy type 1. Sharma et al. RR pres ent as. RR complicate. In view of wide variations.
Due to lack of universally accepted criteria for. Materials and Methods. This is a pr ospective study where patients. Hospital in Delhi over a thr ee-year period from. Patient selection was. Safdarjung Hospital. The clinical inclusion criteria.
The patient presenting. Sixty non-reaction biopsies from. The patient age, sex and. Ridley-Jopling leprosy classification, presence or. Skin biopsy and Histopathologic examination. Four millimeter punch biops y or were t aken by. All three pathologists involved in. Bef ore recording their. E dema within. Large to bizarr e shaped giant. Mucous Genital. Brutally Exit. Entrail's Parasites.
Dirty Cremation. Sexual Funeral. Dead Eyes. Macabre Cannibals. Perversited Orgasm. Piece By Piece. Cold Carcass. Suppurated Mosquitos. Massacring Zombie. Stiffs From Churchyard. Secretion Of Penis. Horrible Exhumation. Bile Cavities. Fester Excretor. Sex Foeticide. Black Casket.
Defecation Of Face. Muscular Detruncation. Fermenting Death. Alcoholic Atrophy. Repulsion Delirium. Septic Rectum. Bitch's Bosom. Psychic Deflorator. Addicted Clitoris. Beast Abbatoir. Pyosisified In Thorax. Screaming Murmur. Mutated Slaughter. Erection Torture. Aorta From Incubator. Molecular Demolition. Pestilent Gravidity. Genital Necropsy. Mouldering Organs. Urinary Gore. Rancid Plasma. Schizophrenic Pathologist. Corroded Leprosy.
Raging Skin. Cardiovascular Morphology. Sacrifical Excruciation. Pungent Aroma. Sickening Asphyxiation. Hallucinogenic Trip. Cadaveric Begin. Gaseous Onslaught. Maturating Corpse. Funeral Feast. Pulverising Dementia. Purulent Meat. Eaten Alive. Fuckin' Death. Anal Muscle. Sadistic Sodomizing. Thrashing Membrane. Rotten To The Core. Slowly Decay. Rigor Mortis.
Plasmatic Gore. Necrolytic Digestion. Hydrogenic Mould. Bacterial Enzyme. Hungry Larvae. Bubbling Viscera. Swarming Of Maggots. Sexy Sluts. Empty Skull. Perversited Flesh. Special studies and clinical correlation can help in difficult cases.
Histiocytic reactions — The foamy histiocytes, which are laden with organisms in lepromatous leprosy, may mimic histiocytic reactions seen with deposition of aluminium chloride a common antiperspirant and haemostatic agent or orthopaedic hardware. Tuberculosis and other mycobacterial infections — Other mycobacterial infections often cause tissue necrosis , and are associated with suppuration.
Special studies may help in the differential. Lymphoma — T-cell lymphomas may be neurotropic and associated with sparse histiocytes, producing a pattern similar to indeterminate leprosy.
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